Miner, MD;
Hatherill, M;
Mave, V;
Gray, GE;
Nachman, S;
Read, SW;
White, RG;
... Churchyard, G; + view all
(2022)
Developing tuberculosis vaccines for people with HIV: consensus statements from an international expert panel.
The Lancet HIV
, 9
(11)
e791-e800.
10.1016/S2352-3018(22)00255-7.
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Abstract
New tuberculosis vaccine candidates that are in the development pipeline need to be studied in people with HIV, who are at high risk of acquiring Mycobacterium tuberculosis infection and tuberculosis disease and tend to develop less robust vaccine-induced immune responses. To address the gaps in developing tuberculosis vaccines for people with HIV, a series of symposia was held that posed six framing questions to a panel of international experts: What is the use case or rationale for developing tuberculosis vaccines? What is the landscape of tuberculosis vaccines? Which vaccine candidates should be prioritised? What are the tuberculosis vaccine trial design considerations? What is the role of immunological correlates of protection? What are the gaps in preclinical models for studying tuberculosis vaccines? The international expert panel formulated consensus statements to each of the framing questions, with the intention of informing tuberculosis vaccine development and the prioritisation of clinical trials for inclusion of people with HIV.
| Type: | Article |
|---|---|
| Title: | Developing tuberculosis vaccines for people with HIV: consensus statements from an international expert panel |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/S2352-3018(22)00255-7 |
| Publisher version: | https://doi.org/10.1016/s2352-3018(22)00255-7 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Humans, Tuberculosis Vaccines, Mycobacterium tuberculosis, HIV Infections, Tuberculosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213400 |
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