Cifuentes, Mariana;
Fuentes, Cecilia;
Tobar, Nicolas;
Acevedo, Ingrid;
Villalobos, Elisa;
Hugo, Eric;
Ben-Jonathan, Nira;
(2012)
Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and adipose tissue.
Molecular and Cellular Endocrinology
, 361
(1-2)
pp. 24-30.
10.1016/j.mce.2012.03.006.
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Abstract
The proinflammatory status of adipose tissue has been linked to the metabolic and cardiovascular consequences of obesity. Human adipose cells express the calcium sensing receptor (CaSR), and its expression is elevated in inflammatory states, such as that associated with obesity. Given the CaSR’s association with inflammation in other tissues, we evaluated its role elevating the adipose expression of inflammatory factors. The CaSR activation by the calcimimatic cinacalcet (5 μM) in adipose tissue and in vitro cultured LS14 adipose cells elicited an elevation in the expression of the proinflammatory cytokines IL6, IL1β, TNFα, and the chemoattractant CCL2. This was in part reverted by SN50, an inhibitor of the inflammatory mediator nuclear factor kappa B (NFκB). Our observations suggest that CaSR activation elevates cytokine and chemokine production, partially mediated by NFκB. These findings support the relevance of the CaSR in the pathophysiology of obesity-induced adipose tissue dysfunction, with an interesting potential for pharmacological manipulation.
| Type: | Article |
|---|---|
| Title: | Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and adipose tissue |
| Location: | Ireland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.mce.2012.03.006 |
| Publisher version: | https://doi.org/10.1016/j.mce.2012.03.006 |
| Language: | English |
| Additional information: | This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | calcium sensing receptor; obesity; cytokines; inflammation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10213203 |
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