Liu, Kathy Y;
Senn, Stephen;
Howard, Robert;
(2025)
Response to letter to the editor.
Alzheimer's & Dementia
, 21
(5)
, Article e70251. 10.1002/alz.70251.
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Abstract
We are pleased that Li and colleagues agree with our recommendation that “the average between-group difference in score change is where the debate and research efforts should be focused to contextualize and evaluate the clinical meaningfulness of the true treatment effect.” However, Li et al. do not address the central point of our article,1, 2 which was that the measurement of within-individual variation attributable to treatment is precluded by the parallel-arm randomized controlled trial (RCT) design typically employed in Alzheimer's disease (AD) treatment trials. This was why we argued that responder analyses risk committing “causal fraud” if differences in “responder” proportions (defined by a threshold of clinically meaningful change) are attributed to the treatment.
| Type: | Article |
|---|---|
| Title: | Response to letter to the editor |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.70251 |
| Publisher version: | https://doi.org/10.1002/alz.70251 |
| Language: | English |
| Additional information: | © The Author(s), 2025. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry > Mental Health of Older People |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10212967 |
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