Masramon Munoz, Marta;
Mathew, Manju;
Clemente, Joey;
Retter, Adam;
Thorley, Natasha;
Kanber, Baris;
Dineen, Eoin;
... Panagiotaki, Eleftheria; + view all
(2025)
Revealing Invisible Prostate Cancer With VERDICT-MRI.
In:
Proceedings of the International Society for Magnetic Resonance in Medicine 2025.
ISMRM
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Abstract
Motivation: Prostate multi-parametric (mp)MRI misses 10-20% of PCa, presenting a need for enhanced imaging techniques. Goal(s): To determine if VERDICT-MRI, when used alongside mpMRI, can improve the detection and characterization of mpMRI-invisible lesions. Approach: We identify patients with mpMRI-invisible lesions from the Histo-MRI clinical trial (n=11). We use slice-to-slice matched whole-slide histology and MRI. We analyze differences in histological cell density, epithelial fraction and VERDICT intracellular volume fraction between mpMRIvisible and -invisible lesions. Results: Using VERDICT-MRI improves the sensitivity of detection of invisible lesions, particularly with high cell density and epithelial fraction. Impact: Integrating VERDICT-MRI into clinical imaging could enhance detection of previously invisible prostate cancer lesions, allowing for more precise stratification and more informed, personalized treatment strategies, potentially improving patient outcomes.
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