Tari, B;
Ben Yehuda, M;
Laurell, AAS;
Ritchie, K;
Dauvilliers, Y;
Ritchie, CW;
Lawlor, B;
... Koychev, I; + view all
(2023)
The indirect relationship between sleep and cognition in the PREVENT cohort: identifying targets for intervention.
Frontiers in Sleep
, 2
, Article 1226824. 10.3389/frsle.2023.1226824.
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Abstract
Introduction: As the global population ages, the economic, societal, and personal burdens associated with worsening cognition and dementia onset are growing. It is therefore becoming ever more critical to understand the factors associated with cognitive decline. One such factor is sleep. Adequate sleep has been shown to maintain cognitive function and protect against the onset of chronic disease, whereas sleep deprivation has been linked to cognitive impairment and the onset of depression and dementia. Objectives: Here, we aim to identify and explore mechanistic links between several sleep parameters, depressive symptoms and cognition in a cohort of middle-aged adults. Methods: We investigated data from the PREVENT dementia programme via structural equation modeling to illustrate links between predictor variables, moderator variables, and two cognitive constructs (i.e., Executive Function and Memory). Results: Our model demonstrated that sleep quality, and total hours of sleep were related to participants' depressive symptoms, and that, participant apathy was related to higher scores on the Epworth Sleepiness and Lausanne NoSAS Scales. Subsequently, depressive symptoms, but not sleep or apathy ratings, were associated with Executive Function. Conclusions: We provide evidence for an indirect relationship between sleep and cognition mediated by depressive symptoms in a middle-aged population. Our results provide a base from which cognition, dementia onset, and potential points of intervention, may be better understood.
| Type: | Article |
|---|---|
| Title: | The indirect relationship between sleep and cognition in the PREVENT cohort: identifying targets for intervention |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/frsle.2023.1226824 |
| Publisher version: | https://doi.org/10.3389/frsle.2023.1226824 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10211618 |
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