Patel, Amit A;
Ginhoux, Florent;
Yona, Simon;
(2021)
Monocytes, macrophages, dendritic cells and neutrophils: an update on lifespan kinetics in health and disease.
Immunology
, 163
(3)
pp. 250-261.
10.1111/imm.13320.
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Abstract
Phagocytes form a family of immune cells that play a crucial role in tissue maintenance and help orchestrate the immune response. This family of cells can be separated by their nuclear morphology into mononuclear and polymorphonuclear phagocytes. The generation of these cells in the bone marrow, to the blood and finally into tissues is a tightly regulated process. Ensuring the adequate production of these cells and their timely removal is key for both the initiation and resolution of inflammation. Insight into the kinetic profiles of innate myeloid cells during steady state and pathology will permit the rational development of therapies to boost the production of these cells in times of need or reduce them when detrimental.
| Type: | Article |
|---|---|
| Title: | Monocytes, macrophages, dendritic cells and neutrophils: an update on lifespan kinetics in health and disease |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/imm.13320 |
| Publisher version: | https://doi.org/10.1111/imm.13320 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Homeostasis; inflammation; kinetics; mononuclear phagocyte; neutrophils |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10210869 |
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