Meshaka, R;
Fitzke, HE;
Barber, J;
Foster, C;
Reid, C;
Allan, E;
Murphy, R;
... Watson, TA; + view all
(2025)
Quantified motility assessment in paediatric inflammatory bowel disease: a multi-reader study.
Pediatric Radiology
10.1007/s00247-025-06273-8.
(In press).
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Abstract
Background: Quantitative bowel motility in inflammatory bowel disease using magnetic resonance enterography (MRE) shows promise as a biomarker of disease activity against histopathological and biochemical markers of inflammation when used by experienced readers in a research setting. Objective: The aim of this study was to test multi-reader agreement in quantified bowel motility by non-experienced readers. Materials and methods: A single-centre, retrospective search included all patients <18 years with paediatric inflammatory bowel disease and more than one MRE between 2012-2022. Cine images from the first two MREs were processed using quantified motility software. Two experienced readers provided a reference standard for response using a consensus sMaRIA (decrease of ≥2 points) and measured the change (Δ) in motility index. Two senior and three junior readers visually assessed response for each patient and recorded Δ motility index. Inter-reader agreement was assessed for each pair of readers as the Bland-Altman bias and limits of agreement for Δ motility index (arbitrary units, a.u.) and %agreement in the Δdirection. Results: Percentage agreement in the Δdirection was fair to excellent. Junior reader agreement with experienced readers was 73-84%, and senior reader agreement with experienced readers was 67-85%. Bland-Altman plots of Δ motility index demonstrated no systematic bias and the junior-experienced readers’ limits of agreement were acceptable. Conclusion: Quantified bowel motility in paediatric inflammatory bowel disease measured by readers of varied experience yields good agreement.
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