Liu, S;
Gaisford, S;
Williams, GR;
(2025)
Ciprofloxacin-loaded electrosprayed lactose particles.
International Journal of Pharmaceutics
, 680
, Article 125748. 10.1016/j.ijpharm.2025.125748.
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Abstract
Bacterial infections persist as a major global health challenge, underscoring the need for the development of advanced drug delivery systems. This study firstly explored the use of electrospraying to generate lactose microparticles loaded with ciprofloxacin (cipro), using polyvinyl alcohol (PVA) as an additive to enhance particle formation. Following optimization, spherical electrosprayed (ES) lactose microparticles were successfully produced with various cipro loadings (in the range of 0.25 %-1.07 % w/w). The electrosprayed particles did not contain any detectable crystalline material. Additionally, it was observed that the ES particles contained residual water, primarily originating from the production process. In terms of drug release, the ES particles exhibited rapid release kinetics within 5 h, suggesting their potential utility in treating acute bacterial infections. Notably, the formulations displayed concentration-dependent antibacterial activity against both Staphylococcus aureus and Pseudomonas aeruginosa, effectively delaying and inhibiting bacterial growth.
| Type: | Article |
|---|---|
| Title: | Ciprofloxacin-loaded electrosprayed lactose particles |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijpharm.2025.125748 |
| Publisher version: | https://doi.org/10.1016/j.ijpharm.2025.125748 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10209763 |
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