Kaliki, Swathi;
Vempuluru, Vijitha S;
Desai, Akruti;
Ji, Xunda;
Zou, Yihua;
Rashid, Riffat;
Sultana, Sadia;
... Didi Fabian, Ido; + view all
(2025)
Lag Time Between Onset of First Symptom and Treatment of Retinoblastoma: Outcomes at Three Years from Recruitment.
Seminars in Ophthalmology
10.1080/08820538.2025.2491004.
(In press).
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Abstract
Purpose: To evaluate the effect of lag time between diagnosis of retinoblastoma (RB) and treatment in patients from 10 countries. Methods: Prospective study of 692 treatment-naïve RB patients from 10 countries followed up for 3 years from recruitment. Results: The mean lag time from the onset of the first symptom to visit to the RB treatment center was 150 days. The mean follow-up duration was 26 months (median, 32 months; range, <1–51 months). A higher socioeconomic status of the country was associated with a lower risk of enucleation: Lower-middle-income countries vs. low-income countries (p<.001), Upper-middle-income vs. low-income countries (p =.009), and high-income countries vs. low-income countries (p =.014). A greater AJCC stage was associated with a greater risk of enucleation: T2 vs. T1 (p<.001) and T3 vs. T1 (p<.001). Increased lag time (p<.001) and AJCC T4 stage (T4 vs. T2; p<.001) were associated with increased risk of death. By Kaplan–Meier analysis, the cumulative incidence of enucleation at 3 months, 1 year, and 3 years was 49%, 55%, and 61%, respectively; and survival at 1, 2, and 3 years was 92%, 88%, and 87%, respectively. Three-year Kaplan–Meier survival estimates were 95% with a lag time of <3 months vs. 83% with a lag time of 3–12 months vs. 62% with a lag time of >12 months. Conclusion: A lower socioeconomic status and greater AJCC stage were associated with an increased risk of enucleation. Increased lag time from the onset of the first symptom to visit the RB treatment center and AJCC T4 stage were associated with an increased risk of death from RB.
| Type: | Article |
|---|---|
| Title: | Lag Time Between Onset of First Symptom and Treatment of Retinoblastoma: Outcomes at Three Years from Recruitment |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/08820538.2025.2491004 |
| Publisher version: | https://doi.org/10.1080/08820538.2025.2491004 |
| Language: | English |
| Additional information: | © 2025 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Ophthalmology, Eye, global, lag time, retinoblastoma, tumor, DIAGNOSIS, PREDICTORS, GROWTH, DELAYS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10209752 |
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