Ramantani, Georgia;
Cserpan, Dorottya;
Tisdall, Martin;
Otte, Willem M;
Dorfmuller, Georg;
Jambaque, Isabelle;
Cross, J Helen;
... Bulteau, Christine; + view all
(2025)
Determinants of intellectual and developmental outcomes in a multicenter pediatric hemispherotomy cohort.
Epilepsia
10.1111/epi.18391.
(In press).
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Cross_Determinants of intellectual and developmental outcomes in a multicenter pediatric hemispherotomy cohort_AAM.pdf Access restricted to UCL open access staff until 29 March 2026. Download (665kB) |
Abstract
OBJECTIVE: This study aimed to identify the determinants of intellectual and developmental outcomes following pediatric hemispherotomy in a large, contemporary multicenter cohort. METHODS: This study aimed to identify the determinants of intellectual and developmental outcomes following pediatric hemispherotomy in a large, contemporary multicenter cohort. RESULTS: This study aimed to identify the determinants of intellectual and developmental outcomes following pediatric hemispherotomy in a large, contemporary multicenter cohort. SIGNIFICANCE: Age at epilepsy onset, underlying etiology, presence of bilateral structural brain abnormalities, and postsurgical ASM management were key determinants of intellectual and developmental outcomes following hemispherotomy. These findings underscore the importance of timely ASM discontinuation as the only modifiable factor that may optimize intellectual and developmental trajectories. Although direct presurgical comparisons were not possible, the observed associations provide valuable insights into factors influencing cognitive outcomes.
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