Pogson, Cathy Margaret;
Austin, Rosalynn;
Patel, Jignesh Prakash;
Wheeler, David Collins;
(2025)
Medication review interventions for adults living with advanced chronic kidney disease: A scoping review.
British Journal of Clinical Pharmacology
, 91
(4)
pp. 1132-1156.
10.1111/bcp.16363.
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Abstract
Structured medication reviews (SMRs) were introduced into the National Health Service (NHS) Primary Care to support the delivery of the NHS Long-Term Plan for medicines optimization. SMRs improve the quality of care, reduce harm and offer value for money. However, evidence to support SMRs for patients with chronic kidney disease (CKD) stage G4-5D with elevated risk of cardiovascular disease and premature mortality is unknown. This scoping review aimed to assess the extent and nature of SMR research in the population of patients with CKD stage G4-5D. Electronic databases were searched on 20 October 2023. Studies were eligible if they described an SMR in adults with CKD stage G4-5D, regardless of the study design. Data detailing the global patterns, population and intervention descriptions, professionals performing SMR, and reported areas for future research were extracted. The extracted outcome data were categorized as clinical, patient-important, medication-related and experience-related. A narrative synthesis was completed. Seventeen studies (81%) were conducted in nephrology outpatient settings, three (14%) during acute hospital admissions and one (5%) within the community pharmacy. Eighteen studies (86%) were quantitative, including five randomized controlled trials. Ten (48%) studies were undertaken in the United States and Canada, and two in Europe (France and Norway). No such studies have been conducted in the United Kingdom. Our review revealed that there is a lack of evidence for SMR as a strategy to reduce polypharmacy and harms from medication for adults with CKD stage G4-5D. Therefore, further research is required in this area.
| Type: | Article |
|---|---|
| Title: | Medication review interventions for adults living with advanced chronic kidney disease: A scoping review |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bcp.16363 |
| Publisher version: | https://doi.org/10.1111/bcp.16363 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2024 The Author(s). British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, adverse drug reactions, co-morbidity, deprescribing, medicines optimisation, morbidity, QUALITY-OF-LIFE, OUTPATIENT HEMODIALYSIS UNIT, DRUG-RELATED PROBLEMS, PHARMACEUTICAL CARE, CONCISE GUIDE, THERAPY MANAGEMENT, OUTCOMES, IMPACT, PHARMACISTS, COMORBIDITY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10208275 |
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