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Characterisation of polymeric nanoparticles for drug delivery

Floyd, Thomas G; Gurnani, Pratik; Rho, Julia Y; (2025) Characterisation of polymeric nanoparticles for drug delivery. Nanoscale , 17 (13) pp. 7738-7752. 10.1039/d5nr00071h. Green open access

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Abstract

Polymeric nanoparticles represent an innovative approach to drug delivery, particularly for addressing complex diseases like cancer. Their nanoscale dimensions facilitate targeted cellular uptake and effective navigation of biological barriers. With a broad range of polymerisation and functionalisation techniques, these nanoparticles can enable precise drug release, enhanced stability, and improved bioavailability while minimising side effects. Compared to conventional carriers, polymeric nanoparticles offer superior stability and versatility. However, despite these beneficial attributes, challenges remain in understanding their dynamic behaviour and interactions within biological systems. This mini-review aims to highlight key characterisation methods for studying polymeric nanocarriers, explore recent advances, and examine current challenges that must be addressed to optimise their therapeutic potential and advance these promising targeted drug delivery systems.

Type: Article
Title: Characterisation of polymeric nanoparticles for drug delivery
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/d5nr00071h
Publisher version: https://doi.org/10.1039/d5nr00071h
Language: English
Additional information: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence, https://creativecommons.org/licenses/by-nc/3.0/.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10208053
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