Jiang, C;
Bai, R;
Somavarapu, S;
(2025)
Inhalable TPGS/DPPC Micelles Coloaded with Curcumin and Icariin for Targeted Lung Cancer Therapy.
ACS Omega
, 10
(15)
pp. 15400-15411.
10.1021/acsomega.5c00008.
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Abstract
Lung cancer, particularly NSCLC, poses a major therapeutic challenge due to drug resistance and the poor aqueous solubility of chemotherapeutic agents, limiting treatment efficacy. This study investigates inhalable micelles for the codelivery of curcumin (CUR) and icariin (ICA), two hydrophobic bioactive compounds with anticancer potential, as a targeted therapeutic approach for NSCLC. The optimized micellar formulation (9:1 TPGS/DPPC) yielded nanomicelles (∼18 nm) with high encapsulation efficiency (∼90%) and a zeta potential of −1.24 mV, demonstrating stability for pulmonary administration. In vitro cytotoxicity studies demonstrated enhanced anticancer activity of CUR- and ICA-loaded micelles against A549 lung cancer cells (IC50 = 3.0 μg/mL), lower than doxorubicin (30 μg/mL), suggesting enhanced cytotoxic potential. Additionally, DPPH assays confirmed that encapsulation preserved curcumin’s functionality. Aerosolization studies demonstrated a high fine particle fraction (67 ± 3%) and emitted fraction (95 ± 1.0%), confirming the micelles’ suitability for deep lung deposition and effective pulmonary drug delivery. These findings highlight the potential of CUR- and ICA-loaded micelles as an inhalable NSCLC treatment, requiring further preclinical investigation.
Type: | Article |
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Title: | Inhalable TPGS/DPPC Micelles Coloaded with Curcumin and Icariin for Targeted Lung Cancer Therapy |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1021/acsomega.5c00008 |
Publisher version: | https://doi.org/10.1021/acsomega.5c00008 |
Language: | English |
Additional information: | Copyright © 2025 The Authors. Published by American Chemical Society. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
URI: | https://discovery.ucl.ac.uk/id/eprint/10208042 |
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