Yang, Ren;
Ma, Xiaohan;
Peng, Feng;
Wen, Jin;
Allahou, Latifa W;
Williams, Gareth R;
Knowles, Jonathan C;
(2025)
Advances in antimicrobial peptides: From mechanistic insights to chemical modifications.
Biotechnology Advances
, 81
, Article 108570. 10.1016/j.biotechadv.2025.108570.
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Abstract
This review provides a comprehensive analysis of antimicrobial peptides (AMPs), exploring their diverse sources, secondary structures, and unique characteristics. The review explores into the mechanisms underlying the antibacterial, immunomodulatory effects, antiviral, antiparasitic and antitumour of AMPs. Furthermore, it discusses the three principal synthesis pathways for AMPs and assesses their current clinical applications and preclinical research status. The paper also addresses the limitations of AMPs, including issues related to stability, resistance, and toxicity, while offering insights into strategies for their enhancement. Recent advancements in AMP research, such as chemical modifications (including amino acid sequence optimisation, terminal and side-chain modifications, PEGylation, conjugation with small molecules, conjugation with photosensitisers, metal ligands, polymerisation, cyclisation and specifically targeted antimicrobial peptides) are highlighted. The goal is to provide a foundation for the future design and optimisation of AMPs.
| Type: | Article |
|---|---|
| Title: | Advances in antimicrobial peptides: From mechanistic insights to chemical modifications |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.biotechadv.2025.108570 |
| Publisher version: | https://doi.org/10.1016/j.biotechadv.2025.108570 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, AMPs, Antibacterial, Clinical, Preclinical, Modifications, PROTEIN-COUPLED RECEPTOR, HERPES-SIMPLEX-VIRUS, RENAL-CELL CARCINOMA, ACUTE BACTERIAL SKIN, IN-VITRO, CATHELICIDIN LL-37, ANTIBACTERIAL PEPTIDES, ENHANCED STABILITY, ESCHERICHIA-COLI, AUREIN 1.2 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10207822 |
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