Qosim, N;
Williams, GR;
Edirisinghe, M;
(2025)
The tailored manufacturing of core (cellulose acetate)-sheath (polyvinylpyrrolidone) polymeric nanofibers for biphasic drug delivery systems using pressure-spinning.
Materials and Design
, 253
, Article 113939. 10.1016/j.matdes.2025.113939.
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Abstract
Pressure-spinning is a straightforward method for manufacturing core-sheath fibers with diameters spanning from the submicrometer to micrometer scale. In this study, for the first time, a combination of cellulose acetate (CA)-polyvinylpyrrolidone (PVP) is utilized as a pressure-spun fiber matrix, despite CA having traditionally been regarded as non-pressure-spinnable. The fibers are then loaded with ibuprofen to create a biphasic drug delivery system. The resulting fibers are amorphous and cylindrical with smooth surfaces, with diameters ranging from 370 nm to 1 µm. It is observed that higher ibuprofen concentrations increase fiber diameter, while the application of higher spinning parameters has the opposite effect. In vitro dissolution tests reveal a dual-phase release profile, with an initial burst release due to the hydrophilic PVP sheath, followed by a sustained release phase attributed to the hydrophobic CA core. The release profile can then be tuned through fiber diameter and drug concentration adjustments. Notably, after 8 weeks of storage under ambient conditions, the fibers maintain an amorphous structure and consistent release profiles, showcasing excellent stability. These findings highlight pressure-spinning as a versatile technique for fabricating core-sheath nanofibers with customizable drug release, offering practical advantages for pharmaceutical applications in terms of enhancing therapeutic precision and patient outcomes.
| Type: | Article |
|---|---|
| Title: | The tailored manufacturing of core (cellulose acetate)-sheath (polyvinylpyrrolidone) polymeric nanofibers for biphasic drug delivery systems using pressure-spinning |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.matdes.2025.113939 |
| Publisher version: | https://doi.org/10.1016/j.matdes.2025.113939 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Core-sheath nanofibers, Core-sheath pressure-spinning, Non-pressure-spinnable material, Biphasic drug delivery, Polymeric fiber |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10207821 |
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