Scott, RV;
Abdel-Malek, M;
Zhu, J;
Tan, J;
Thayabaran, D;
Valaiyapathi, R;
Padam, P;
... Tan, TMM; + view all
(2025)
Thyroid reference ranges in pregnancy utilizing an Abbott Alinity platform in a multi-ethnic population in the UK.
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
10.1177/00045632251333286.
(In press).
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Abstract
BACKGROUND: Maternal thyroid function significantly affects fetal development. However, thyroid hormone concentrations change dynamically throughout pregnancy rendering non-pregnancy reference ranges inaccurate. We aimed to establish the trimester-, population-, and assay-specific reference ranges for thyroid hormones in pregnancy using the recently introduced Abbott Alinity thyroid function test, according to American Thyroid Association 2017 Guidelines for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. METHODS: This study of 663, iodine-replete and thyroid peroxidase (TPO)-antibody negative female determined trimester-specific reference ranges for thyroid stimulating hormone (TSH), free thyroxine (fT4), and free tri-iodothyronine (fT3) using Abbott Alinity assays in accordance with ATA guidelines. Study participants were drawn from a multi-ethnic population with 49% non-white participants. RESULTS: First trimester reference ranges were TSH 0.06–2.73 mIU/l, fT4 9.9–15.3 pmol/l, and fT3 3.4–5.6 pmol/l. Second trimester reference ranges were TSH 0.02–2.47 mIU/l, fT4 8.5–14.4 pmol/l, and fT3 3.3–5.5 pmol/l. In the third trimester, TSH ranges were 0.41–2.80 mIU/l, fT4 7.6–12.3 pmol/l, and fT3 3.1–5.0 pmol/l. There were no significant differences in any trimester-specific analyte reference ranges when white and non-white populations were compared. CONCLUSIONS: These reference ranges support the clinical care of female from diverse backgrounds with thyroid dysfunction in pregnancy using the thyroid function tests available on the Abbott Alinity platform. STUDY REGISTRATION: These reference ranges support the clinical care of female from diverse backgrounds with thyroid dysfunction in pregnancy using the thyroid function tests available on the Abbott Alinity platform.
| Type: | Article |
|---|---|
| Title: | Thyroid reference ranges in pregnancy utilizing an Abbott Alinity platform in a multi-ethnic population in the UK |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/00045632251333286 |
| Publisher version: | https://doi.org/10.1177/00045632251333286 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Analytes, Analytical systems, Clinical studies, Laboratory methods, Pregnancy, Thyroid hormones |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10207785 |
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