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Does the coexistence of pain and depressive symptoms accelerate cognitive decline?

Tofani, Patricia Silva; Maximo, Roberta de Oliveira; Cochar-Soares, Natalia; Ramirez, Paula Camila; Luiz, Mariane Marques; Lima, Sara Souza; da Silva, Thais Barros Pereira; ... Alexandre, Tiago da Silva; + view all (2025) Does the coexistence of pain and depressive symptoms accelerate cognitive decline? Aging and Mental Health , 29 (2) pp. 334-342. 10.1080/13607863.2024.2392737.

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Abstract

Objectives: Investigate whether the coexistence of pain and depressive symptoms is a risk factor for cognitive decline in individuals aged 50 or older.// Method: Longitudinal trajectory study involving 4,718 participants from the English Longitudinal Study of Ageing (ELSA). Joint pain was self-reported, and intensity was classified as mild, moderate/intense. Depressive symptoms were investigated using the Centre for Epidemiologic Studies Depression Scale (CES-D-8 ≥ 4). The sample was divided into six groups: no pain and no depression (NP/NDe), mild pain and no depression (MP/NDe), moderate/intense pain and no depression (M-IP/NDe), no pain and depression (NP/De), mild pain and depression (MP/De), and moderate/intense pain and depression (M-IP/De). The outcome of interest was performance in memory, executive function, and global cognition. Generalised linear mixed models were used to analyse performance in the cognitive domains and global cognition score as a function of pain and depressive symptoms during 12 years of follow-up.// Results: Over time, individuals with M-IP/De had a greater memory decline (-0.038 SD/year, 95%CI: −0.068 to −0.007) and the global cognition score (-0.033 SD/year, 95%CI: −0.063 to −0.002) than those with NP/NDe.// Conclusion: The coexistence of moderate/intense pain and depressive symptoms is a risk factor for the decline of global cognition and memory.//

Type: Article
Title: Does the coexistence of pain and depressive symptoms accelerate cognitive decline?
Location: England
DOI: 10.1080/13607863.2024.2392737
Publisher version: https://doi.org/10.1080/13607863.2024.2392737
Language: English
Additional information: This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Pain, depressive symptoms, cognitive function, memory, executive function
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/10207744
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