Foster, E;
Carr, AJ;
(2025)
Macrophages and Age-Related Macular Degeneration.
Advances in Experimental Medicine and Biology
, 1468
pp. 9-13.
10.1007/978-3-031-76550-6_2.
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Abstract
Age-related macular degeneration (AMD) is characterised by the dysfunction of the retinal pigment epithelium (RPE), deposition of drusen and degeneration of the overlying photoreceptors, leading to the loss of central vision. AMD is a complex and multifactorial disease, with the greatest risk factor being age. As we age, changes occur to our immune system, a phenomenon known as inflammageing. There is mounting evidence indicating a role for the immune system in the development, progression, pathology and potentially, treatment of AMD. However, the specific contribution played by immune cells remains unclear. This chapter discusses evidence implicating a role for the circulating macrophages in AMD.
| Type: | Article |
|---|---|
| Title: | Macrophages and Age-Related Macular Degeneration |
| Location: | United States |
| DOI: | 10.1007/978-3-031-76550-6_2 |
| Publisher version: | https://doi.org/10.1007/978-3-031-76550-6_2 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10207329 |
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