Gómez Penedo, Juan Martín;
Meglio, Manuel;
Flückiger, Christoph;
Wienicke, Frederik J;
Breunese, Jasmijn;
Menchetti, Marco;
Rucci, Paola;
... Driessen, Ellen; + view all
(2025)
Interpersonal problems as a predictor of treatment outcome in adult depression: An individual participant data meta-analysis.
Clinical Psychology Review
, 118
, Article 102570. 10.1016/j.cpr.2025.102570.
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Abstract
OBJECTIVES: Interpersonal problems are a fundamental feature of depression, but study-level meta-analyses of their association with treatment outcome have been limited by heterogeneity in primary studies' analyses and reported results. We conducted a pre-registered individual participant data meta-analysis (IPD-MA) to examine this relationship for adult depression. This meta-analytic strategy can reduce variability by standardizing data analysis across primary studies. METHODS: We included studies examining the efficacy of five treatments for adult depression and assessing interpersonal problems at baseline. One-stage IPD-MA was conducted with three-level mixed models to determine whether baseline overall interpersonal distress, agency, and communion predicted depressive symptom level at post-treatment, 12-month, and 24-month follow-up. The moderating effect of treatment type was also investigated. RESULTS: Ten studies (including n = 1282 participants) met inclusion criteria. Only overall interpersonal distress was negatively related with outcomes at post-treatment (γ = 0.11, CI95[0.06, 0.16], r = 0.11), 12-month follow-up (γ = 0.17, CI95[0.08, 0.25], r = 0.17), and 24-month follow-up (γ = 0.16, CI95[0.05, 0.26], r = 0.16), indicative of smaller effect sizes. The agency and communion dimensions were not significantly related to outcome. Treatment type did not significantly moderate interpersonal distress-outcome associations. DISCUSSIONS: Results show a small association between patient baseline overall interpersonal distress and subsequent depression treatment outcome in brief treatments for depression. Further studies might require to account for therapist effects. Registration number osf.io/u46t7
| Type: | Article |
|---|---|
| Title: | Interpersonal problems as a predictor of treatment outcome in adult depression: An individual participant data meta-analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cpr.2025.102570 |
| Publisher version: | https://doi.org/10.1016/j.cpr.2025.102570 |
| Language: | English |
| Additional information: | © 2025 The Authors. Published by Elsevier Ltd. under a Creative Commons license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | interpersonal distress, outcome, depression, treatment, individual participants data meta-analysis, IPD |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10206708 |
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