Liu, Yinan;
(2025)
Preparation of Core-shell Doxorubicin-loaded Nanoparticles by Coaxial Electrospraying for the Combined Cancer Therapy and Theranostics.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
This study explores the development and optimization of core-shell doxorubicin-loaded nanoparticles using coaxial electrospraying for applications in cancer combined therapy and theranostics. The primary objective was to establish coaxial electrospraying as a viable technique for fabricating nanoparticles capable of controlled drug release, thereby enhancing therapeutic efficacy while minimizing side effects. The research involved the preparation of various nanoparticle formulations, including matrix doxorubicin-loaded PLGA nanoparticles, core-shell doxorubicin-loaded PLGA nanoparticles, core-shell dual-drug doxorubicin/quercetin-loaded nanoparticles, and gold-coated doxorubicin-loaded nanoparticles. The study optimized key parameters of the coaxial electrospraying process, such as polymer concentration, flow rate, and voltage, and characterized the nanoparticles using techniques including SEM, TEM, DSC, XRD, and FTIR. The findings demonstrated the successful formation of core-shell nanoparticles with sustained drug release profiles, superior encapsulation efficiency, and enhanced in vitro cytotoxicity against cancer cells compared to free drugs and matrix nanoparticles. Additionally, the study explored the synergistic effects of co-delivery quercetin with doxorubicin in one nanoparticle system, achieving improved anti-cancer efficacy while reducing doxorubicin-induced cardiotoxicity. Furthermore, we also verified the feasibility of preparing gold nanoparticle-coated core-shell nanoparticles by coaxial electrospraying, which opened a new path for the development of cancer theranostics in the future. The research contributes significantly to the field by advancing the understanding of core-shell nanoparticle fabrication via coaxial electrospraying and its potential in drug delivery systems. However, limitations such as the need for further in vivo testing and scalability challenges were identified. Future research should focus on overcoming these challenges, exploring new drug combinations, and advancing towards clinical trials to fully realize the potential of these innovative nanoparticle systems in cancer therapy and beyond.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Preparation of Core-shell Doxorubicin-loaded Nanoparticles by Coaxial Electrospraying for the Combined Cancer Therapy and Theranostics |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2025. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10206507 |
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