Lu, Wei-Ting;
Kanu, Nnennaya;
(2025)
FAT1 alterations contribute to chromosomal instability in cancer cells.
Nature Cell Biology
, 27
(1)
pp. 12-13.
10.1038/s41556-024-01559-9.
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Kanu_FAT1 alterations contribute to chromosomal instability in cancer cells_AAM.pdf - Accepted Version Access restricted to UCL open access staff until 9 July 2025. Download (56MB) |
Abstract
Combining genomics data from the TRACERx non-small-cell lung cancer (NSCLC) cohort and experimental data, we report that alterations in FAT1 are selected early during lung cancer evolution and cause chromosomal instability and whole-genome doubling.
| Type: | Article |
|---|---|
| Title: | FAT1 alterations contribute to chromosomal instability in cancer cells |
| DOI: | 10.1038/s41556-024-01559-9 |
| Publisher version: | https://doi.org/10.1038/s41556-024-01559-9 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10206227 |
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