Higham, James P;
Colquhoun, David;
(2024)
The affinity-efficacy problem: an essential part of pharmacology education.
Royal Society Open Science
, 11
(7)
, Article 240487. 10.1098/rsos.240487.
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Abstract
A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist. These properties are inextricably linked and cannot be easily separated in any case where the binding of a ligand induces a conformation change in its receptor. Consequently, binding curves and concentration-response relationships for receptor agonists have no straightforward interpretation. This problem - the affinity-efficacy problem - remains overlooked and misunderstood despite it being recognized in 1987. To avoid the further propagation of this misunderstanding, we propose in this review that the affinity-efficacy problem should be included in the core curricula for pharmacology undergraduates proposed by the British Pharmacological Society and the International Union of Basic and Clinical Pharmacology (IUPHAR).
| Type: | Article |
|---|---|
| Title: | The affinity-efficacy problem: an essential part of pharmacology education |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rsos.240487 |
| Publisher version: | https://doi.org/10.1098/rsos.240487 |
| Language: | English |
| Additional information: | © 2024 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, agonism, ligand binding, receptor theory, affinity, efficacy, SINGLE-CHANNEL RECORD, APPARENT OPEN TIMES, SHUT TIMES, DISTRIBUTIONS, RECEPTORS, AGONISM, EVENTS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10205618 |
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