Jarzebowski, P;
Hay, YA;
Paulsen, O;
(2024)
Optogenetic and chemogenetic studies of spatial navigation.
In: Grafman, Jordan Henry, (ed.)
Encyclopedia of the Human Brain.
(pp. 18-32).
Elsevier
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Abstract
Optogenetics and chemogenetics have become essential techniques in systems neuroscience. The development of these tools has massively benefited our understanding of the neuronal circuits involved in spatial navigation. In particular, they have been crucial in untangling the local network involved in the emergence of spatially selective cells and have played a major role in elucidating how brain areas involved in spatial navigation communicate and coordinate their activities. In this article, we focus on the hippocampo-entorhinal network, highlighting the opportunities offered by these tools while also acknowledging their potential caveats.
| Type: | Book chapter |
|---|---|
| Title: | Optogenetic and chemogenetic studies of spatial navigation |
| ISBN-13: | 9780128204818 |
| DOI: | 10.1016/B978-0-12-820480-1.00111-X |
| Publisher version: | https://doi.org/10.1016/b978-0-12-820480-1.00111-x |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | CA1, calcium imaging, chemogenetics, grid cells, hippocampus, learning, medial entorhinal cortex, navigation, neuronal circuits, optogenetics, place cells, spatial representations, sharp-wave ripple, theta |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10205613 |
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