Crawford, Hannah;
Dimitriadi, Maria;
Bassin, Jatinder;
Cook, Michael T;
Abelha, Thais Fedatto;
Calvo-Castro, Jesus;
(2022)
Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review.
Chemistry - A European Journal
, 28
(72)
, Article e202202366. 10.1002/chem.202202366.
Preview |
PDF
Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores A Review.pdf - Published Version Download (12MB) | Preview |
Abstract
The last decade has seen an increasingly large number of studies reporting on the development of novel small organic conjugated systems for mitochondrial imaging exploiting optical signal transduction pathways. Mitochondria are known to play a critical role in a number of key biological processes, including cellular metabolism. Importantly, irregularities on their working function are nowadays understood to be intimately linked to a range of clinical conditions, highlighting the importance of targeting mitochondria for therapeutic benefits. In this work we carry out an in-depth evaluation on the progress to date in the field to pave the way for the realization of superior alternatives to those currently existing. The manuscript is structured by commonly used chemical scaffolds and comprehensively covers key aspects factored in design strategies such as synthetic approaches as well as photophysical and biological characterization, to foster collaborative work among organic and physical chemists as well as cell biologists.
| Type: | Article |
|---|---|
| Title: | Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/chem.202202366 |
| Publisher version: | https://doi.org/10.1002/chem.202202366 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, bioimaging, fluorescence, mitochondria, optoelectronics, organic materials, RATIOMETRIC FLUORESCENT-PROBE, ENDOGENOUS HYDROGEN-SULFIDE, NEAR-INFRARED-EMISSION, LARGE STOKES SHIFT, ONE-POT SYNTHESIS, SELECTIVE DETECTION, OXIDATIVE STRESS, SO2 DERIVATIVES, LIVING CELLS, LIVE CELLS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10204820 |
Archive Staff Only
 |
View Item |
