Gobé, Joshua;
Rositi, Hugo;
Vacavant, Antoine;
Rivière, Margaux;
Po, Chrystelle;
Chourrout, Matthieu;
Chauveau, Fabien;
(2024)
High-resolution brain tractography from X-ray phase-contrast images.
The European Physical Journal Plus
, 139
(7)
, Article 571. 10.1140/epjp/s13360-024-05357-y.
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High-resolution brain tractography from X-ray phase-contrast images.pdf - Accepted Version Access restricted to UCL open access staff until 3 July 2025. Download (33MB) |
Abstract
X-ray phase contrast tomography (XPCT) can produce high contrast isotropic images of biological samples in only a few minutes thanks to the unique properties of the synchrotron X-ray beam. XPCT of brain tissue provides an exquisite contrast of white matter, which could be exploited for 3D directional analysis. In this article, we present the first XPCT-based pipeline to perform white matter tractography on rodent brains. We observed the disorganization of white matter in the vicinity of focal demyelinating lesions in the corpus callosum. The ability to obtain an isotropic, high-resolution tractogram is an important landmark which could drive further interest of the neuroscience community toward XPCT.
Type: | Article |
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Title: | High-resolution brain tractography from X-ray phase-contrast images |
DOI: | 10.1140/epjp/s13360-024-05357-y |
Publisher version: | http://dx.doi.org/10.1140/epjp/s13360-024-05357-y |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Science & Technology, Physical Sciences, Physics, Multidisciplinary, Physics |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
URI: | https://discovery.ucl.ac.uk/id/eprint/10204292 |
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