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Sustained real-time and video-rate interventional optical ultrasound imaging

Stafford-Williams, Robert; Colchester, Richard; Bodian, Semyon; Cardiff, Seán; Maneas, Efthymios; Zhang, Edward; Beard, Paul; ... Alles, Erwin; + view all (2025) Sustained real-time and video-rate interventional optical ultrasound imaging. Journal of Biomedical Optics (In press).

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Abstract

Significance: Minimally invasive surgery offers improved recovery times and reduced complication risk compared to open surgery. However, effective image acquisition probes suitable for deployment in clinical workflows are key to the success of such procedures. Fibre-optic optical ultrasound (OpUS) offers strong potential for interventional image guidance due to its small lateral probe dimensions and high imaging resolution, but to date, such miniature imaging probes have only yielded M-mode (single image line) or still images.// Aim: Here, we present a motorised actuation approach to fibre-optic interventional OpUS imaging that enables sustained and video-rate imaging whilst retaining its small form factor.// Approach: A novel fabrication method utilising a commercial laser cutter is presented that yields partially forward-emitting OpUS sources ideally suited for interventional image guidance. These transmitters were incorporated into a miniature imaging probe with a width of just 600 µm (1.8 mm with protective encapsulation) and combined with a linear actuator to synthesise an imaging aperture at the distal end of the probe through manipulation at its proximal end.// Results: The presented imaging paradigm achieved real-time, 2D OpUS imaging at frame rates of up to 7 Hz and was capable of high-resolution imaging (94 µm axial, 241 µm lateral). The imaging performance of the presented imaging system was assessed using various imaging phantoms, and its clinical suitability was confirmed by emulating endobronchial OpUS imaging through a commercial bronchoscope.// Conclusions: These results constitute the first-ever sustained, real-time dynamic imaging using a side-viewing single-element OpUS probe via rapid actuation, which enables a wide range of applications in minimally invasive surgical guidance.

Type: Article
Title: Sustained real-time and video-rate interventional optical ultrasound imaging
Publisher version: https://epubs.siam.org/journal-authors#openaccess
Language: English
Additional information: This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Interventional optical ultrasound imaging, linearly actuated aperture scanning, oblique optical ultrasound emitter, pulmonary optical ultrasound
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10204279
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