Vivarelli, Marina;
Samuel, Susan;
Coppo, Rosanna;
Barratt, Jonathan;
Bonilla-Felix, Melvin;
Haffner, Dieter;
Gibson, Keisha;
... Nakanishi, Koichi; + view all
(2025)
IPNA clinical practice recommendations for the diagnosis and management of children with IgA nephropathy and IgA vasculitis nephritis.
Pediatric Nephrology
, 40
(2)
pp. 533-569.
10.1007/s00467-024-06502-6.
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Abstract
IgA nephropathy and IgA vasculitis with nephritis, albeit rare, represent two relatively frequent glomerular conditions in childhood. Compared to adults, pediatric IgA nephropathy has a more acute presentation, most frequently with synpharyngitic macrohematuria and histologically with more intense inflammation and less intense chronic damage. Management of these conditions is controversial and supported by little high-quality evidence. The paucity of evidence is due to the disease heterogeneity, its inter-ethnic variability, and the difficulty of extrapolating data from adult studies due to the peculiarities of the condition in children. IgA vasculitis with nephritis is a kidney manifestation of a systemic disorder, typical of the pediatric age, in which both the diagnosis of kidney involvement and its management are poorly defined, and an interdisciplinary approach is crucial. Both conditions can have a profound and long-lasting impact on kidney function and the global health of affected children. The International Pediatric Nephrology Association has therefore convened a diverse international group of experts from different disciplines to provide guidance on the recommended management of these conditions in children and to establish common definitions and define priorities for future high-quality, evidence-based collaborative studies for the benefit of children.
| Type: | Article |
|---|---|
| Title: | IPNA clinical practice recommendations for the diagnosis and management of children with IgA nephropathy and IgA vasculitis nephritis |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00467-024-06502-6 |
| Publisher version: | https://doi.org/10.1007/s00467-024-06502-6 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Pediatrics, Urology & Nephrology, IgA nephropathy, IgA vasculitis nephritis, Children, Treatment, Guideline, HENOCH-SCHONLEIN PURPURA, IMMUNOGLOBULIN-A NEPHROPATHY, TERM-FOLLOW-UP, RENAL-TRANSPLANT RECIPIENTS, RANDOMIZED CONTROLLED-TRIAL, MYCOPHENOLATE-MOFETIL, RISK-FACTORS, DOUBLE-BLIND, ORAL METHYLPREDNISOLONE, OXFORD CLASSIFICATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10203167 |
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