Desai, Sneha;
Camporesi, Elena;
Brinkmalm, Gunnar;
Alatza, Argyro;
Wood, Jack I;
Tripathi, Takshashila;
Bez, Sumi;
... Edwards, Frances A; + view all
(2024)
Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer’s disease without mutations in MAPT.
bioRxiv: Cold Spring Harbor, NY, USA.
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Abstract
Introducing heterozygous humanized tau to AppNL-F/NL-F knock-in mice results in the first mouse model of Alzheimer’s disease in which age and amyloid-β pathology interact to initiate neurofibrillary tau tangle pathology, not dependent on mutations in MAPT. Gradual progression from amyloid-β to tau pathology in NLFTaum/h mice opens possibilities for understanding processes precipitating clinical stages of Alzheimer’s disease and development of translatable therapies to prevent the onset of tau pathology.
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