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Left ventricular non-noncompaction: The mitral valve prolapse of the 21st century?

Captur, G; Flett, AS; Jacoby, DL; Moon, JC; (2013) Left ventricular non-noncompaction: The mitral valve prolapse of the 21st century? International Journal of Cardiology , 164 (1) pp. 3-6. 10.1016/j.ijcard.2012.05.018. Green open access

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Abstract

A spongiform epidemic is upon us - myocardial trabeculae are everywhere as left ventricular noncompaction (LVNC) ingratiates itself into modern day cardiology. Current understanding of the condition is evolving but remains incomplete, and brings to mind the chronicles of another great cardiac story: mitral valve prolapse. Anecdote suggests that many individuals with prominent trabeculae may be being falsely labelled with a disease - LVNC - using poor echocardiographic and cardiovascular magnetic resonance criteria. Until we have robust diagnostic criteria, aetiology, clinicopathological significance and prognosis, the risk of casualties from ascertainment bias will remain. We should look to history and learn from past mistakes - specifically from the mitral valve prolapse story to show the way forward for LVNC. Meanwhile, clinicians (and patients) should be wary, bearing in mind the possibility that they might be seeing LVNNC - left ventricular non-noncompaction. © 2012 Elsevier Ireland Ltd.

Type: Article
Title: Left ventricular non-noncompaction: The mitral valve prolapse of the 21st century?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijcard.2012.05.018
Publisher version: https://doi.org/10.1016/j.ijcard.2012.05.018
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Heart failure, Cardiomyopathy, Left ventricle, Mitral valve insufficiency, Mitral valve prolapse
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/10199502
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