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Incidence and outcomes of vasa praevia in the United Kingdom [version 1; peer review: 2 approved, 1 approved with reservations, 1 not approved]

Attilakos, George; David, Anna L; Tunn, Ruth; Knight, Marian; Brocklehurst, Peter; (2024) Incidence and outcomes of vasa praevia in the United Kingdom [version 1; peer review: 2 approved, 1 approved with reservations, 1 not approved]. NIHR Open Research , 4 , Article 49. 10.3310/nihropenres.13696.1. Green open access

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Abstract

Background: Vasa praevia is an obstetric condition in which the fetal vessels run through the membrane over the internal cervical os, unprotected by the placenta or umbilical cord. It is associated with perinatal mortality if not diagnosed antenatally. We investigated the incidence and outcomes of vasa praevia in the UK.// Methods: We conducted a population-based descriptive study using the UK Obstetric Surveillance System (UKOSS). Cases were identified prospectively through monthly UKOSS submissions form all UK hospitals with obstetrician-led maternity units. All women diagnosed with vasa praevia who gave birth between 1st December 2014 and 30th November 2015 were included. The main outcome was incidence of vasa praevia with 95% confidence intervals, using 2015 maternities as the denominator.// Results: Fifty-one women met the case definition. The incidence of diagnosed vasa praevia was 6.64 per 100,000 maternities (95% CI 5.05-8.73). Of 198 units, 10 (5%) had a vasa praevia screening programme; one of these 10 units identified 25% of the antenatally diagnosed cases. Among women who had vasa praevia diagnosed or suspected antenatally (n=28, 55%), there were no perinatal deaths or hypoxic ischaemic encephalopathy (HIE). Twenty-four women with antenatal diagnosis were hospitalised at a median gestation of 32 weeks and caesarean section was scheduled at a median gestation of 36 weeks. When vasa praevia was diagnosed peripartum (n=23, 45%), the perinatal mortality rate was 37.5% and 47% of survivors developed HIE. // Conclusions: The incidence of diagnosed vasa praevia was lower than anticipated. There was high perinatal mortality and morbidity for cases not diagnosed antenatally. The incidence of antenatally identified cases was much higher in the few centres that actively screened for this condition, and the perinatal outcomes were better. However, this group were all delivered by caesarean section and may include women who would not have experienced any adverse perinatal outcome.

Type: Article
Title: Incidence and outcomes of vasa praevia in the United Kingdom [version 1; peer review: 2 approved, 1 approved with reservations, 1 not approved]
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.3310/nihropenres.13696.1
Publisher version: http://dx.doi.org/10.3310/nihropenres.13696.1
Language: English
Additional information: © 2024 Attilakos G et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Keywords: Vasa praevia, UK Obstetric Surveillance System, incidence, outcomes, perinatal mortality, pregnancy, surveillance, velamentous cord insertion
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10198199
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