Kader, Rawen;
Hadjinicolaou, Andreas V;
Burr, Nicholas E;
Paul, Bassett;
Ahmad, Omer F;
Lasse, Pedersen;
Manish, Chand;
... Lovat, Laurence B; + view all
(2024)
SYSTEMATIC REVIEW AND META-ANALYSIS: THE THREE-YEAR POST-COLONOSCOPY COLORECTAL CANCER RATE AS PER THE WEO METHODOLOGY.
Clinical Gastroenterology and Hepatology
10.1016/j.cgh.2024.07.039.
(In press).
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Abstract
BACKGROUND AND AIMS: In 2018, the World Endoscopy Organization (WEO) introduced standardised methods for calculating post-colonoscopy colorectal cancer-3yr rates (PCCRC-3yr). This systematic review aimed to calculate the global PCCRC-3yr according to the WEO methodology, its change over time, and to measure the association between risk factors and PCCRC occurrences. METHODS: We searched five databases from inception until January 2024 for PCCRC-3yr studies that strictly adhered to the WEO methodology. The overall pooled PCCRC-3yr was calculated. For risk factors and time-trend analyses, the pooled PCCRC-3yr and odds ratio (OR) of subgroups were compared. RESULTS: Several studies failed to adhere to the WEO methodology. Eight studies from four Western European and two Northern American countries were included, totalling 220,106 detected-colorectal cancers (CRC) and 18,148 PCCRCs between 2002-2017. The pooled Western World PCCRC-3yr was 7.5% (95%CI 6.4%-8.7%). The PCCRC-3yr significantly (p<0.05) decreased from 7.9% (95%CI 6.6%-9.4%) in 2006 to 6.7% (95%CI 6.1%-7.3%) in 2012 (OR 0.79 (95%CI 0.72-0.87)). There were significantly higher rates for people with inflammatory bowel disease (PCCRC-3yr 29.3%, OR 6.17 (95%CI 4.73-8.06)), prior CRC (PCCRC-3yr 29.8%, OR 3.03 (95% CI 1.34-4.72)), proximal CRC (PCCRC-3yr 8.6%, OR 1.51 (95%CI 1.41-1.61), diverticular disease (PCCRC 3-yr 11.6%, OR 1.74 (95%CI 1.37-2.10)) and female sex (PCCRC-3yr 7.9%, OR 1.15 (95%CI 1.11-1.20)). CONCLUSION: According to the WEO methodology, the Western World PCCRC-3yr was 7.5%. Reassuringly, this has decreased over time, but further work is required to identify the reasons for PCCRCs, especially in higher-risk groups. We devised a WEO methodology checklist to increase its adoption and standardise the categorisation of patients in future PCCRC-3yr studies.
| Type: | Article |
|---|---|
| Title: | SYSTEMATIC REVIEW AND META-ANALYSIS: THE THREE-YEAR POST-COLONOSCOPY COLORECTAL CANCER RATE AS PER THE WEO METHODOLOGY |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cgh.2024.07.039 |
| Publisher version: | http://dx.doi.org/10.1016/j.cgh.2024.07.039 |
| Language: | English |
| Additional information: | © 2024 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Keywords: | Colorectal cancer, colonoscopy, post-colonoscopy colorectal cancer |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10197062 |
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