Vranceanu, M;
Filip, L;
Hegheș, SC;
de Lorenzo, D;
Cozma-Petruț, A;
Ghitea, TC;
Stroia, CM;
... Popa, DS; + view all
(2024)
Genes Involved in Susceptibility to Obesity and Emotional Eating Behavior in a Romanian Population.
Nutrients
, 16
(16)
, Article 2652. 10.3390/nu16162652.
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Abstract
Obesity, a significant public health concern with high prevalence in both adults and children, is a complex disorder arising from the interaction of multiple genes and environmental factors. Advances in genome-wide association studies (GWAS) and sequencing technologies have identified numerous polygenic causes of obesity, particularly genes involved in hunger, satiety signals, adipocyte differentiation, and energy expenditure. This study investigates the relationship between six obesity-related genes (CLOCK, FTO, GHRL, LEP, LEPR, MC4R) and their impact on BMI, WC, HC, WHR, and emotional eating behavior in 220 Romanian adults. Emotional eating was assessed using the validated Emotional Eating Questionnaire (EEQ). Our analysis revealed significant variability in obesity-related phenotypes and emotional eating behaviors across different genotypes. Specifically, CLOCK/CC, FTO/AA, and LEP/AA genotypes were strongly associated with higher obesity metrics and emotional eating scores, while GHRL/TT and MC4R/CC were linked to increased BMI and WHR. The interplay between genetic predisposition and emotional eating behavior significantly influenced BMI and WHR, indicating a complex relationship between genetic and behavioral factors. This study, the first of its kind in Romania, provides a foundation for targeted interventions to prevent and reduce obesity and suggests potential strategies for gene expression modulation to mitigate the effects of emotional eating. Adopting a ‘One Health’ approach by creating an evidence base derived from both human and animal studies is crucial for understanding how to control obesity.
| Type: | Article |
|---|---|
| Title: | Genes Involved in Susceptibility to Obesity and Emotional Eating Behavior in a Romanian Population |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/nu16162652 |
| Publisher version: | http://dx.doi.org/10.3390/nu16162652 |
| Language: | English |
| Additional information: | Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) |
| Keywords: | CLOCK, FTO, GHRL, LEP, LEPR, MC4R, diet, emotional eating, genes, obesity, precision nutrition, Humans, Romania, Feeding Behavior, Obesity, Female, Male, Adult, Genetic Predisposition to Disease, Emotions, Middle Aged, Body Mass Index, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Genotype, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Young Adult, Surveys and Questionnaires, Receptor, Melanocortin, Type 4 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10196860 |
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