Alsugeir, Dana;
Adesuyan, Matthew;
Talaulikar, Vikram;
Wei, Li;
Whittlesea, Cate;
Brauer, Ruth;
(2024)
Common mental health diagnoses arising from or coinciding with menopausal transition and prescribing of SSRIs/SNRIs medications and other psychotropic medications.
Journal of Affective Disorders
, 364
pp. 259-265.
10.1016/j.jad.2024.08.036.
Preview |
Text
Brauer et al. JAD24.pdf - Published Version Download (605kB) | Preview |
Abstract
Background: Women with menopausal transition (MT) have an elevated risk of experiencing common mental health diagnoses (CMHD: depression or anxiety). There is no recent data comparing the rate, and treatment, of CMHD between men and women. // Methods: In this population-based study, incidence rates (IR) per 100 person-years-at-risk (PYAR) for men and women ≥45 years registered with an UK primary care practice between 2010 and 2021 were estimated. Incidence rate ratios (IRR) with 95 % confidence intervals (CIs) of CMHD were estimated using men as a reference. We measured first prescriptions for psychotropic medications received within 12 months after CMHD. For selective serotonin reuptake inhibitors (SSRIs) /selective norepinephrine reuptake inhibitors (SNRIs), we measured the IR of prescribing per 100 PYAR, by 10-year bands. Proportion of SSRIs/SNRIs prescribing was estimated per 100 persons. // Results: Rates of anxiety and depressive disorders were 1.68 and 1.69 per 100 PYAR in women aged 45–54 years-old compared to 0.91 and 1.20 per 100 PYAR in men, with IRR of 1.84 (95 % CI 1.72–1.97) and 1.44 (1.35–1.53) respectively. SSRIs/SNRIs were the most prescribed medication; in 2021, IRs for SSRIs/SNRIs were 13.4 per 100 PYAR in both sexes. In 2021, the proportion of SSRIs/SNRIs prescribing was 50.67 per 100 women and 41.91 per 100 men. // Limitations: MT is assumed based on women's age as menopause onset is rarely recorded in primary care databases. // Conclusions: Women ≥45 years experienced more CMHD compared to men, especially 45–54 years-olds, which coincides with MT. The proportion of SSRIs/SNRIs prescribing was higher in women.
| Type: | Article |
|---|---|
| Title: | Common mental health diagnoses arising from or coinciding with menopausal transition and prescribing of SSRIs/SNRIs medications and other psychotropic medications |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jad.2024.08.036 |
| Publisher version: | http://dx.doi.org/10.1016/j.jad.2024.08.036 |
| Language: | English |
| Additional information: | Copyright © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/bync/4.0/). |
| Keywords: | Menopause; Perimenopause; Depression; Anxiety; SSRI; SNRI |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10196550 |
Archive Staff Only
 |
View Item |
