Borek, Aleksandra;
Ledda, Alice;
Pouwels, Koen;
Butler, Chris;
Hayward, Gail;
Walker, Ann;
Robotham, Julie;
(2024)
Stop antibiotics when you feel better? Opportunities, challenges and research directions.
JAC-Antimicrobial Resistance
, 6
(5)
, Article dlae147. 10.1093/jacamr/dlae147.
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Abstract
Shortening standard antibiotic courses and stopping antibiotics when patients feel better are two ways to reduce exposure to antibiotics in the community, and decrease the risks of antimicrobial resistance and antibiotic side effects. While evidence shows that shorter antibiotic treatments are non-inferior to longer ones for infections that benefit from antibiotics, shorter courses still represent average treatment durations that might be suboptimal for some. In contrast, stopping antibiotics based on improvement or resolution of symptoms might help personalize antibiotic treatment to individual patients and help reduce unnecessary exposure. Yet, many challenges need addressing before we can consider this approach evidence-based and implement it in practice. In this viewpoint article, we set out the main evidence gaps and avenues for future research.
| Type: | Article |
|---|---|
| Title: | Stop antibiotics when you feel better? Opportunities, challenges and research directions |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/jacamr/dlae147 |
| Publisher version: | https://doi.org/10.1093/jacamr/dlae147 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10196310 |
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