UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Sodium valproate is associated with cortical thinning of disease-specific areas in juvenile myoclonic epilepsy

Crespo Pimentel, Bernardo; Kuchukhidze, Giorgi; Xiao, Fenglai; Caciagli, Lorenzo; Höfler, Julia; Rainer, Lucas; Kronbichler, Martin; ... Wandschneider, Britta; + view all (2024) Sodium valproate is associated with cortical thinning of disease-specific areas in juvenile myoclonic epilepsy. Journal of Neurology, Neurosurgery and Psychiatry 10.1136/jnnp-2024-333703. (In press). Green open access

[thumbnail of Duncan_vpa_manuscript.pdf]
Preview
Text
Duncan_vpa_manuscript.pdf

Download (381kB) | Preview

Abstract

BACKGROUND: Juvenile myoclonic epilepsy (JME) is associated with cortical thinning of the motor areas. The relative contribution of antiseizure medication to cortical thickness is unknown. We aimed to investigate how valproate influences the cortical morphology of JME. METHODS: In this cross-sectional study, individuals with JME with and without valproate, with temporal lobe epilepsy (TLE) with valproate and controls were selected through propensity score matching. Participants underwent T1-weighted brain imaging and vertex-wise calculation of cortical thickness. RESULTS: We matched 36 individuals with JME on valproate with 36 individuals with JME without valproate, 36 controls and 19 individuals with TLE on valproate. JME on valproate showed thinning of the precentral gyri (left and right, p<0.001) compared with controls and thinning of the left precentral gyrus when compared with JME not on valproate (p<0.01) or to TLE on valproate (p<0.001). Valproate dose correlated negatively with the thickness of the precentral gyri, postcentral gyri and superior frontal gyrus in JME (left and right p<0.0001), but not in TLE. CONCLUSIONS: Valproate was associated with JME-specific and dose-dependent thinning of the cortical motor regions. This suggests that valproate is a key modulator of cortical morphology in JME, an effect that may underlie its high efficacy in this syndrome.

Type: Article
Title: Sodium valproate is associated with cortical thinning of disease-specific areas in juvenile myoclonic epilepsy
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2024-333703
Publisher version: http://dx.doi.org/10.1136/jnnp-2024-333703
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10195642
Downloads since deposit
20Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item