Ciurtin, Coziana;
Helmy, Ghada Adly;
Ferreira, Alexia Correia;
Manson, Jessica J;
Jury, Elizabeth C;
McDonnell, Thomas;
(2024)
A tale of two functions: C-reactive protein complement-ary structures and their role in rheumatoid arthritis.
Clinical Immunology
, 265
, Article 110281. 10.1016/j.clim.2024.110281.
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Abstract
C-reactive protein (CRP) is an inflammatory biomarker with associated clinical utility in a wide number of inflammatory disorders, including rheumatoid arthritis (RA). The interaction of CRP with pro-inflammatory cytokines has been explored before, however its role in complement regulation is more subtle, where CRP is capable of both up and downregulating the complement cascade. CRP is produced in a pentameric form and can dissociate to a monomeric form in circulation which has significant implications for its ability to interact with receptors and binding partners. This dichotomy of CRP structure could have relevance in patients with RA who have significant dysfunction in their complement cascade and also widely varying CRP levels including at the time of flare. This review aims to bring together current knowledge of CRP in its various forms, its effects on complement function and how this could influence pathology in the context of RA.
| Type: | Article |
|---|---|
| Title: | A tale of two functions: C-reactive protein complement-ary structures and their role in rheumatoid arthritis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clim.2024.110281 |
| Publisher version: | http://dx.doi.org/10.1016/j.clim.2024.110281 |
| Language: | English |
| Additional information: | Copyright © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | C reactive protein; Complement; Structural dichotomy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10193666 |
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