Chen, K;
Wang, Y;
Li, D;
Wu, R;
Wang, J;
Wei, W;
Zhu, W;
... He, Y; + view all
(2024)
Biological clock regulation by the PER gene family: a new perspective on tumor development.
Frontiers in Cell and Developmental Biology
, 12
, Article 1332506. 10.3389/fcell.2024.1332506.
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Abstract
The Period (PER) gene family is one of the core components of the circadian clock, with substantial correlations between the PER genes and cancers identified in extensive researches. Abnormal mutations in PER genes can influence cell function, metabolic activity, immunity, and therapy responses, thereby promoting the initiation and development of cancers. This ultimately results in unequal cancers progression and prognosis in patients. This leads to variable cancer progression and prognosis among patients. In-depth studies on the interactions between the PER genes and cancers can reveal novel strategies for cancer detection and treatment. In this review, we aim to provide a comprehensive overview of the latest research on the role of the PER gene family in cancer.
| Type: | Article |
|---|---|
| Title: | Biological clock regulation by the PER gene family: a new perspective on tumor development |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fcell.2024.1332506 |
| Publisher version: | https://doi.org/10.3389/fcell.2024.1332506 |
| Language: | English |
| Additional information: | © 2024 Chen, Wang, Li, Wu, Wang, Wei, Zhu, Xie, Feng and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Biological behavior, cancer therapy, carcinogenic effect, circadian rhythm, period gene |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10193229 |
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