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Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis

Aprea, MG; Schiavetti, I; Portaccio, E; Ballerini, C; Bonavita, S; Buscarinu, M; Calabrese, M; ... Amato, MP; + view all (2024) Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis. Multiple Sclerosis Journal , 30 (6) pp. 707-713. 10.1177/13524585241232266. Green open access

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Abstract

Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes. Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection. Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020–2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score–based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders. Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32–3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations. Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes.

Type: Article
Title: Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/13524585241232266
Publisher version: http://dx.doi.org/10.1177/13524585241232266
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Multiple sclerosis, pregnancy, COVID-19, SARS-CoV-2 infection, maternal outcomes, fetal outcomes, DIAGNOSTIC-CRITERIA, CORONAVIRUS, REVISIONS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10192983
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