Xiong, Tianzhu;
Tarikere, Shreeharsha;
Rosser, Neil;
Li, Xueyan;
Yago, Masaya;
Mallet, James;
(2023)
A polygenic explanation for Haldane's rule in butterflies.
Proceedings of the National Academy of Sciences (PNAS)
, 120
(44)
, Article e2300959120. 10.1073/pnas.2300959120.
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Abstract
Two robust rules have been discovered about animal hybrids: Heterogametic hybrids are more unfit (Haldane s rule), and sex chromosomes are disproportionately involved in hybrid incompatibility (the large-X/Z effect). The exact mechanisms causing these rules in female heterogametic taxa such as butterflies are unknown but are suggested by theory to involve dominance on the sex chromosome. We investigate hybrid incompatibilities adhering to both rules in Papilio and Heliconius butterflies and show that dominance theory cannot explain our data. Instead, many defects coincide with unbalanced multilocus introgression between the Z chromosome and all autosomes. Our polygenic explanation predicts both rules because the imbalance is likely greater in heterogametic females, and the proportion of introgressed ancestry is more variable on theZchromosome.Wealso show that mapping traits polygenic on a single chromosome in backcrosses can generate spurious large-effect QTLs. This mirage is caused by statistical linkage among polygenes that inflates estimated effect sizes. By controlling for statistical linkage, most incompatibility QTLs in our hybrid crosses are consistent with a polygenic basis. Since the two genera are very distantly related, polygenic hybrid incompatibilities are likely common in butterflies.
Type: | Article |
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Title: | A polygenic explanation for Haldane's rule in butterflies |
Location: | United States |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1073/pnas.2300959120 |
Publisher version: | https://doi.org/10.1073/pnas.2300959120 |
Language: | English |
Additional information: | © 2023 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). |
Keywords: | Haldane’s rule, hybrid incompatibility, polygenic trait, QTL, Lepidoptera |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
URI: | https://discovery.ucl.ac.uk/id/eprint/10192903 |
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