Gauld, Oliver M;
Packer, Adam M;
Russell, Lloyd E;
Dalgleish, Henry WP;
Iuga, Maya;
Sacadura, Francisco;
Roth, Arnd;
... Häusser, Michael; + view all
(2024)
A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception.
Neuron
10.1016/j.neuron.2024.04.015.
(In press).
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Abstract
To investigate which activity patterns in sensory cortex are relevant for perceptual decision-making, we combined two-photon calcium imaging and targeted two-photon optogenetics to interrogate barrel cortex activity during perceptual discrimination. We trained mice to discriminate bilateral whisker deflections and report decisions by licking left or right. Two-photon calcium imaging revealed sparse coding of contralateral and ipsilateral whisker input in layer 2/3, with most neurons remaining silent during the task. Activating pyramidal neurons using two-photon holographic photostimulation evoked a perceptual bias that scaled with the number of neurons photostimulated. This effect was dominated by optogenetic activation of non-coding neurons, which did not show sensory or motor-related activity during task performance. Photostimulation also revealed potent recruitment of cortical inhibition during sensory processing, which strongly and preferentially suppressed non-coding neurons. Our results suggest that a pool of non-coding neurons, selectively suppressed by network inhibition during sensory processing, can be recruited to enhance perception.
| Type: | Article |
|---|---|
| Title: | A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2024.04.015 |
| Publisher version: | http://dx.doi.org/10.1016/j.neuron.2024.04.015 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Cortex; sensory processing; two-photon imaging; optogenetics; behavior; sparse coding; all-optical interrogation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10192307 |
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