Oliveira de Andrade, Matheus;
(2024)
Mathematical Modelling of Bubble Nucleation in Acoustic Fields.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
Ultrasound-induced bubble activity is a promising phenomenon underlying the non-invasive ablation of soft tissue via histotripsy. Histotripsy is a non-invasive, repeatable and non-ionizing modality of surgery that takes advantage of the bioeffects of ultrasound propagation in attenuating media, employing heat deposition and ultrasound tensile pressures to different extents in triggering the nucleation of bubbles within millimetric volumes of soft tissue. Central to the clinical translation of histotripsy as a surgical modality are the challenges of establishing operating windows in which bubble nucleation takes place in terms of electrical power provided to the transducer, pulse duration, medium temperature, and ultrasound waveforms. The models developed herein aim to aid in the design of effective histotripsy protocols to be employed with current clinical high intensity focused ultrasound (HIFU) systems, as well as the understanding of the fundamental mechanisms that affect bubble formation and activity in soft tissue. While a number of studies have explored the effects of different experimental parameters in histotripsy, a rigorous formulation of the physics of metastable volumes under HIFU sonication is absent from the literature. The main objectives of this thesis are: (i) to evaluate the current understanding of ultrasound bubble nucleation, integrating knowledge from experimental and theoretical sources towards evaluating its limitations and synthesizing new information; (ii) to design and derive models of bubble nucleation in ultrasound pressure and temperature fields that are parameterised and validated against existing experimental evidence in histotripsy; and (iii) to assess the scope, validity and limitations of any models developed herein through quantitative and qualitative comparison of simulations with published experimental evidence.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Mathematical Modelling of Bubble Nucleation in Acoustic Fields |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2024. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10192115 |
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