Vergori, Alessandra;
Cozzi-Lepri, Alessandro;
Tavelli, Alessandro;
Mazzotta, Valentina;
Azzini, Anna Maria;
Gagliardini, Roberta;
Mastrorosa, Ilaria;
... Vax ICONA ORCHESTRA Study group; + view all
(2024)
SARS-CoV-2 mRNA vaccination and short-term changes in viral load and CD4/CD8 T-cell counts in people living with HIV.
International Journal of Infectious Diseases
, 144
, Article 107065. 10.1016/j.ijid.2024.107065.
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Abstract
OBJECTIVES: To investigate if SARS-CoV-2 mRNA vaccination has an impact on HIV-related viro-immunological parameters. METHODS: PWH of the VAXICONA-ORCHESTRA cohort who received ≥1 dose of SARS-CoV-2 mRNA vaccine and for whom paired measures of immuno-virological markers [Viral Load (VL), CD4, CD8 count 1 month before and after a vaccine dose (VD)] were available, were included. Paired t-test and generalized estimating equation linear regression analyses were used to study changes over ± 1 month around the VD. Subgroup analyses were performed. RESULTS: 510 PWH enrolled: median age 55 y (IQR 46-60), CD4 and CD8 count 489(287-719) and 790 (59-1104) cells/mm3. 81% received 3 VDs. After a median of 28 days (3-53) from VD, CD4 count increased by +15 cells/mm3 (SD ±129.7; p=0.001), CD8 by +12 (±250.5; p=0.199), VL decreased by -0.11 log10 (±0.88; p=0.001). Similar results were observed after restricting the analysis to viro-suppressed PWH, with CD4 ≤200/mm3, more than 6 months of ART before VD and after excluding previous COVID-19. CONCLUSIONS: A small significant increase in CD4 count and a negligible drop in HIV-RNA were observed. Our findings are consistent with the hypothesis that SARS-CoV-2 mRNA vaccine can prime CD4 T spike specific cells even in the more immuno-compromised PWH.
| Type: | Article |
|---|---|
| Title: | SARS-CoV-2 mRNA vaccination and short-term changes in viral load and CD4/CD8 T-cell counts in people living with HIV |
| Location: | Canada |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijid.2024.107065 |
| Publisher version: | http://dx.doi.org/10.1016/j.ijid.2024.107065 |
| Language: | English |
| Additional information: | © 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Keywords: | CD4 count, CD8 count, HIV, HIV RNA, mRNA SARS-CoV-2 vaccine, viro-immunological changes |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10191816 |
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