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Protein-Based Scaffolds for Musculoskeletal Tissue Repair and Regeneration

Rashidi, Narjes; Tamaddon, Maryam; Liu, Chaozong; (2023) Protein-Based Scaffolds for Musculoskeletal Tissue Repair and Regeneration. In: Maia, FRA and Oliveira, JM and Reis, RL, (eds.) Handbook of the Extracellular Matrix. (pp. 1-34). Springer, Cham

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Abstract

The musculoskeletal system, a main structure of the human body, plays a crucial role in movement, safeguarding internal organs, supporting the production of blood cells (hematopoiesis), and maintaining postural stability. Damage or loss to the tissues of the musculoskeletal system impairs mobility and quality of life. Tissue engineering and regenerative medicine have significantly contributed to developing new therapeutic approaches for the treatment of musculoskeletal disorders. The use of protein-based biomaterials has been rapidly growing over the last decade. Proteins mimic the extracellular matrix and have enzymatic degradation with non-toxic degradation products. They have superior bioactivity that promotes cell interaction and stimulates desired biological functions. This chapter discusses MS injuries, diseases, clinical specifications with respect to the composition of the musculoskeletal system and their characteristics, clinical requirements for the protein-based biomaterials and their application in MS tissue engineering, as well as the most common techniques used for the fabrication of protein-based scaffolds.

Type: Book chapter
Title: Protein-Based Scaffolds for Musculoskeletal Tissue Repair and Regeneration
ISBN-13: 978-3-030-92090-6
DOI: 10.1007/978-3-030-92090-6_12-1
Publisher version: https://doi.org/10.1007/978-3-030-92090-6_12-1
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10191773
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