Saadullah Khani, Noushin;
Hudson, Georgie;
Mills, Georgina;
Ramesh, Soumita;
Varney, Lauren;
Cotic, Marius;
Abidoph, Rosemary;
... Bramon, Elvira; + view all
(2024)
A systematic review of pharmacogenetic testing to guide antipsychotic treatment.
Nature Mental Health
10.1038/s44220-024-00240-2.
(In press).
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Abstract
Pharmacogenomics could optimize antipsychotic treatment by preventing adverse drug reactions, improving treatment efficacy or relieving the cost burden on the healthcare system. Here we conducted a systematic review to investigate whether pharmacogenetic testing in individuals undergoing antipsychotic treatment influences clinical or economic outcomes. On 12 January 2024, we searched MEDLINE, EMBASE, PsycINFO and Cochrane Centrale Register of Controlled Trials. The results were summarized using a narrative approach and summary tables. In total, 13 studies were eligible for inclusion in the systematic review. The current evidence base is either in favor of pharmacogenetics-guided prescribing or showed no difference between pharmacogenetics and treatment as usual for clinical and economic outcomes. In the future, we require randomized controlled trials with sufficient sample sizes that provide recommendations for patients who take antipsychotics based on a broad, multigene panel, with consistent and comparable clinical outcomes.
| Type: | Article |
|---|---|
| Title: | A systematic review of pharmacogenetic testing to guide antipsychotic treatment |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s44220-024-00240-2 |
| Publisher version: | https://doi.org/10.1038/s44220-024-00240-2 |
| Language: | English |
| Additional information: | © The Author(s), 2024. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Genetics research, Pharmacogenetics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10191172 |
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