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Mitochondrial Permeability Transition, Cell Death and Neurodegeneration

Baev, Artyom Y; Vinokurov, Andrey Y; Potapova, Elena V; Dunaev, Andrey V; Angelova, Plamena R; Abramov, Andrey Y; (2024) Mitochondrial Permeability Transition, Cell Death and Neurodegeneration. Cells , 13 (7) , Article 648. 10.3390/cells13070648. Green open access

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Abstract

Neurodegenerative diseases are chronic conditions occurring when neurons die in specific brain regions that lead to loss of movement or cognitive functions. Despite the progress in understanding the mechanisms of this pathology, currently no cure exists to treat these types of diseases: for some of them the only help is alleviating the associated symptoms. Mitochondrial dysfunction has been shown to be involved in the pathogenesis of most the neurodegenerative disorders. The fast and transient permeability of mitochondria (the mitochondrial permeability transition, mPT) has been shown to be an initial step in the mechanism of apoptotic and necrotic cell death, which acts as a regulator of tissue regeneration for postmitotic neurons as it leads to the irreparable loss of cells and cell function. In this study, we review the role of the mitochondrial permeability transition in neuronal death in major neurodegenerative diseases, covering the inductors of mPTP opening in neurons, including the major ones—free radicals and calcium—and we discuss perspectives and difficulties in the development of a neuroprotective strategy based on the inhibition of mPTP in neurodegenerative disorders.

Type: Article
Title: Mitochondrial Permeability Transition, Cell Death and Neurodegeneration
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/cells13070648
Publisher version: http://dx.doi.org/10.3390/cells13070648
Language: English
Additional information: Copyright © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: Mitochondrial permeability transition; cell death; neurodegeneration; neuron; astrocyte
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10190897
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