de Guimaraes, Thales AC;
de Guimaraes, Isabela MC;
Ali, Naser;
Kalitzeos, Angelos;
Michaelides, Michel;
(2024)
In-Depth Retinal Sensitivity Assessment With the MP3 Type S Microperimeter: A Methods Study.
TVST
, 13
(4)
, Article 14. 10.1167/tvst.13.4.14.
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Abstract
PURPOSE: Retinal sensitivity is frequently listed as an end point in clinical trials, often with long working practices. The purpose of this methods study was to provide a new workflow and reduced test time for in-depth characterization of retinal sensitivity. METHODS: A workflow for the MP3-S microperimeter with detailed functional characterization of the retina under photopic, mesopic, and scotopic conditions was evaluated. Grids of 32 and 28 test positions for photopic/mesopic and scotopic, respectively, were tested in 12 healthy individuals and compared with an established 68-point grid for test time, mean sensitivity (MS), and bivariate contour ellipse area (BCEA). RESULTS: The mean test time (range; ±SD) was 10.5 minutes (8.4-14.9; ±2.0) in the 68-point grid and 4.3 minutes (3.8-5.0; ±0.4) in the 32-point grid, which was significantly different (P < 0.0001). The mean of difference in test time (±SD; 95% confidence interval) was 6.1 minutes (±2.0; 4.6-7.6). MS and BCEA were significantly correlated between grids (r = 0.89 and 0.74; P = 0.0005 and 0.014, respectively). Mean test time of subjects who underwent the full protocol (n = 4) was 2.15 hours. CONCLUSIONS: The protocol suggested herein appears highly feasible with in-depth characterization of retinal function under different testing conditions and in a short test time. TRANSLATIONAL RELEVANCE: The protocol described herein allows for characterization of the retina under different testing conditions and in a short test time, which is relevant due to its potential for patient prognostication and follow-up in clinical settings and also given its increasing role as a clinical trial end point.
| Type: | Article |
|---|---|
| Title: | In-Depth Retinal Sensitivity Assessment With the MP3 Type S Microperimeter: A Methods Study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1167/tvst.13.4.14 |
| Publisher version: | http://dx.doi.org/10.1167/tvst.13.4.14 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Keywords: | Humans, Retina |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10190849 |
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