Brombal, Luca;
Arfelli, Fulvia;
Brun, Francesco;
Di Trapani, Vittorio;
Endrizzi, Marco;
Menk, Ralf;
Perion, Paola;
... Olivo, Alessandro; + view all
(2024)
Edge-illumination spectral phase-contrast tomography.
Physics in Medicine & Biology
, 69
(7)
, Article 075027. 10.1088/1361-6560/ad3328.
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Abstract
Following the rapid, but independent, diffusion of X-ray spectral and phase-contrast systems, this work demonstrates the first combination of spectral and phase-contrast computed tomography (CT) obtained by using the edge-illumination technique and a CdTe small-pixel (62 μm) spectral detector. A theoretical model is introduced, starting from a standard attenuation-based spectral decomposition and leading to spectral phase-contrast material decomposition. Each step of the model is followed by quantification of accuracy and sensitivity on experimental data of a test phantom containing different solutions with known concentrations. An example of a micro CT application (20 μm voxel size) on an iodine-perfusedex-vivomurine model is reported. 
The work demonstrates that spectral-phase contrast combines the advantages of spectral imaging, i.e. high-Z material discrimination capability, and phase-contrast imaging, i.e. soft tissue sensitivity, yielding simultaneously mass density maps of water, calcium, and iodine with an accuracy of 1.1%, 3.5%, and 1.9% (root mean square errors), respectively. Results also show a 9-fold increase in the signal-to-noise ratio of the water channel when compared to standard spectral decomposition. The application to the murine model revealed the potential of the technique in the simultaneous 3D visualization of soft tissue, bone, and vasculature. While being implemented by using a broad spectrum (pink beam) at a synchrotron radiation facility (Elettra, Trieste, Italy), the proposed experimental setup can be readily translated to compact laboratory systems including conventional X-ray tubes.
| Type: | Article |
|---|---|
| Title: | Edge-illumination spectral phase-contrast tomography |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1361-6560/ad3328 |
| Publisher version: | http://dx.doi.org/10.1088/1361-6560/ad3328 |
| Language: | English |
| Additional information: | Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. |
| Keywords: | Edge illumination, Photon-counting detector, Spectral imaging, X-ray phase-contrast imaging, X-ray tomography |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10190596 |
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