Schrag, Anette; Kostev, Karel; (2024) Association of antihypertensives and Parkinson’s disease in a primary care population matched for underlying diagnosis. PLoS ONE , 19 (3) , Article e0299985. 10.1371/journal.pone.0299985.

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Abstract

Purpose: To examine the association of several antihypertensive medication classes with incidence of Parkinson’s disease (PD), taking into account possible underlying conditions.// Methods: In a case-control study based on a large primary care database and including 21,981 PD cases and 21,981 non-PD controls matched for age, sex, and possible treatment indications associations with different antihypertensive medication groups, including diuretics, betablockers, calcium channel blockers, angiotensin-converting enzyme inhibitors and angiotensin-II receptor-blockers and PD were examined.// Results: Antihypertensive medications overall were associated with a lower risk of subsequent diagnosis of PD (OR: 0.94, 95% CI 0.90–0.97), with the negative association most significant for medications acting on the renin–angiotensin–aldosterone system. A positive association with diagnosis of PD was only seen for betablockers and restricted to those with relatively young age and not in those with longer treatment duration.// Conclusion: When taking into account underlying diagnoses, antihypertensive medications overall were associated with a reduced incidence of PD.

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