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Association of antihypertensives and Parkinson’s disease in a primary care population matched for underlying diagnosis

Schrag, Anette; Kostev, Karel; (2024) Association of antihypertensives and Parkinson’s disease in a primary care population matched for underlying diagnosis. PLoS ONE , 19 (3) , Article e0299985. 10.1371/journal.pone.0299985. Green open access

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Abstract

Purpose: To examine the association of several antihypertensive medication classes with incidence of Parkinson’s disease (PD), taking into account possible underlying conditions.// Methods: In a case-control study based on a large primary care database and including 21,981 PD cases and 21,981 non-PD controls matched for age, sex, and possible treatment indications associations with different antihypertensive medication groups, including diuretics, betablockers, calcium channel blockers, angiotensin-converting enzyme inhibitors and angiotensin-II receptor-blockers and PD were examined.// Results: Antihypertensive medications overall were associated with a lower risk of subsequent diagnosis of PD (OR: 0.94, 95% CI 0.90–0.97), with the negative association most significant for medications acting on the renin–angiotensin–aldosterone system. A positive association with diagnosis of PD was only seen for betablockers and restricted to those with relatively young age and not in those with longer treatment duration.// Conclusion: When taking into account underlying diagnoses, antihypertensive medications overall were associated with a reduced incidence of PD.

Type: Article
Title: Association of antihypertensives and Parkinson’s disease in a primary care population matched for underlying diagnosis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0299985
Publisher version: https://doi.org/10.1371/journal.pone.0299985
Language: English
Additional information: © 2024 Schrag, Kostev. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. https://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10190292
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