Hwang, Angela;
Mehra, Vedika;
Chhetri, Jyoti;
Ali, Samira;
Tran, Maxine;
Roddie, Claire;
(2024)
Current Treatment Options for Renal Cell Carcinoma: Focus on
Cell-Based Immunotherapy.
Cancers
, 16
(6)
, Article 1209. 10.3390/cancers16061209.
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Abstract
Renal cell carcinoma (RCC) affects over 400,000 patients globally each year, and 30% of patients present with metastatic disease. Current standard of care therapy for metastatic RCC involve TKIs and ICIs, including combinatorial strategies, but this offers only modest clinical benefit. Novel treatment approaches are warranted, and cell-based immunotherapies for RCC hold significant promise. These are currently being tested in the pre-clinical setting and in early phase clinical trials. Here, we review the landscape of cellular immunotherapy for RCC in the context of currently available therapies, with a particular focus on defining the current best antigenic targets, the range of cell therapy products being explored in RCC, and how advanced engineering solutions may further enhance these therapies in the RCC space.
| Type: | Article |
|---|---|
| Title: | Current Treatment Options for Renal Cell Carcinoma: Focus on Cell-Based Immunotherapy |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/cancers16061209 |
| Publisher version: | https://doi.org/10.3390/cancers16061209 |
| Language: | English |
| Additional information: | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
| Keywords: | renal cell carcinoma; immunotherapy; chimeric antigen receptor (CAR) T-cells; engineered TCR T-cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10190282 |
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