He, X;
Maung, S;
Ramasamy, A;
Mohamed, MO;
Bajaj, R;
Yap, NAL;
Karaduman, M;
... Bourantas, CV; + view all
(2024)
Efficacy of Coronary Calcium Score in Predicting Coronary Artery Morphology in Patients With Obstructive Coronary Artery Disease.
Journal of the Society for Cardiovascular Angiography and Interventions
, 3
(3)
, Article 101308. 10.1016/j.jscai.2024.101308.
Preview |
PDF
1-s2.0-S2772930324000152-main.pdf - Published Version Download (2MB) | Preview |
Abstract
BACKGROUND: Coronary artery calcium score (CACS) is an established marker of coronary artery disease (CAD) and has been extensively used to stratify risk in asymptomatic individuals. However, the value of CACS in predicting plaque morphology in patients with advanced CAD is less established. The present analysis aims to assess the association between CACS and plaque characteristics detected by near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) imaging in patients with obstructive CAD. METHODS: Seventy patients with obstructive CAD underwent coronary computed tomography angiography (CTA) and 3-vessel NIRS-IVUS imaging were included in the present analysis. The CTA data were used to measure the CACS in the entire coronary tree and the segments assessed by NIRS-IVUS, and these estimations were associated with the NIRS-IVUS measurements at a patient and segment level. Results: In total, 65 patients (188 segments) completed the study protocol and were included in the analysis. A weak correlation was noted between the CACS, percent atheroma volume (r = 0.271, P =.002), and the calcific burden measured by NIRS-IVUS (r = 0.648, P <.001) at patient-level analysis. Conversely, there was no association between the CACS and the lipid content, or the incidence of high-risk plaques detected by NIRS. Linear regression analysis at the segment level demonstrated an association between the CACS and the total atheroma volume (coefficient, 0.087; 95% CI, 0.024-0.149; P =.008) and the calcific burden (coefficient, 0.117; 95% CI, 0.048-0.186; P =.001), but there was no association between the lipid content or the incidence of high-risk lesions. CONCLUSIONS: In patients with obstructive CAD, the CACS is not associated with the lipid content or plaque phenotypes. These findings indicate that the CACS may have a limited value for screening or stratifying cardiovascular risk in symptomatic patients with a high probability of CAD.
| Type: | Article |
|---|---|
| Title: | Efficacy of Coronary Calcium Score in Predicting Coronary Artery Morphology in Patients With Obstructive Coronary Artery Disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jscai.2024.101308 |
| Publisher version: | https://doi.org/10.1016/j.jscai.2024.101308 |
| Language: | English |
| Additional information: | © 2024 The Author(s). Published by Elsevier Inc. on behalf of the Society for Cardiovascular Angiography and Interventions Foundation under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | coronary artery disease, coronary calcium score, coronary computed tomography angiography, near-infrared spectroscopy-intravascular ultrasound, risk stratification, vulnerable plaque |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10189976 |
Archive Staff Only
 |
View Item |
